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STAT1 monoclonal antibody

CAT: 0384-MB66581-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB66581-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The Stat1 transcription factor is activated in response to a large number of ligands and is essential for responsiveness to IFN-α and IFN-γ. Phosphorylation of Stat1 at Tyr701 induces Stat1 dimerization, nuclear translocation, and DNA binding. Stat1 protein exists as a pair of isoforms, Stat1α (91 kDa) and the splice variant Stat1β (84 kDa) . In most cells, both isoforms are activated by IFN-α, but only Stat1α is activated by IFN-γ. The inappropriate activation of Stat1 occurs in many tumors. In addition to tyrosine phosphorylation, Stat1 is also phosphorylated at Ser727 through a p38 mitogen-activated protein kinase (MAPK) -dependent pathway in response to IFN-α and other cellular stresses. Serine phosphorylation may be required for the maximal induction of Stat1-mediated gene activation.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84
Swiss Prot
P42224
Reactivity
Human, Monkey
Immunogen
Purified recombinant human STAT1 protein fragments expressed in E.coli
Conjugation
Unconjugated
Related Pathways
ErbB HER Signaling, Jak Stat : IL-6 Receptor Signaling, Inhibition of Apoptosis
Applications
WB, IP
Dilution
WB (1/500 - 1/1000), IP (1/10 - 1/50)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 84 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of STAT1 protein.
Applications Notes
Western blot analysis of STAT1 expression in Hela (A), MCF7 (B), COS7 (C), SW480 (D), A549 (E) whole cell lysates.
Host or Source
Mouse

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