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STAT3 monoclonal antibody

CAT: 0384-MB66575-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB66575-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The Stat3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors and is required for murine fetal development. Research studies have shown that Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure, or cell maturation stage. It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
APRF; Signal transducer and activator of transcription 3; Acute-phase response factor
Swiss Prot
P40763
Reactivity
Human, Mouse, Rat, Monkey, Hamster
Immunogen
Purified recombinant human STAT3 protein fragments expressed in E.coli
Conjugation
Unconjugated
Related Pathways
ErbB HER Signaling, Jak Stat : IL-6 Receptor Signaling, Inhibition of Apoptosis, Regulation of Microtubule Dynamics, SAPK JNK Signaling Cascades
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 79 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of STAT3 protein.
Applications Notes
Western blot analysis of STAT3 expression in C6 (A), NIH3T3 (B), K562 (C), Jurkat (D), Hela (E), MCF7 (F), COS7 (G) whole cell lysates.
Host or Source
Mouse

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