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RhoA polyclonal antibody

CAT: 0384-BS67782-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67782-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Rho family small GTPases, including Rho, Rac and cdc42, act as molecular switches, regulating processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP. A third level of regulation is provided by the stoichiometric binding of Rho GDP dissociation inhibitor (RhoGDI) . RhoA, RhoB and RhoC are highly homologous, but appear to have divergent biological functions. Carboxy-terminal modifications and differences in subcellular localization allow these three proteins to respond to and act on distinct signaling molecules. Functions of RhoA, the most highly studied of these three, include regulation of actomyosin contractility, cytokinesis, focal adhesion assembly and cell polarity.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
ARH12; ARHA; RHO12; Transforming protein RhoA; Rho cDNA clone 12; h12
Swiss Prot
P61586
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human RhoA. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
Regulation of Actin Dynamics, Adherens Junction signaling, Regulation of Microtubule Dynamics, SAPK JNK Signaling Cascades, TGFβ Smad signaling
Applications
WB, IHC, IF/ICC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 23 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of RhoA protein.
Applications Notes
Western blot analysis of RhoA expression in NIH3T3 (A), mouse lung (B) whole cell lysates.
Host or Source
Rabbit

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MBS2529762-01RHOA Polyclonal Antibody

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