MCOLN2 polyclonal antibody

• Background:

  The mucolipins are a family of cation channel proteins designated mucolipin 1, mucolipin 2 and mucolipin 3. Mucolipin 2 is a lysosomal protein that inter_x0002_acts with the ARF6-associated pathway through co-localization with the cargo proteins CD59 and MHC1. These interactions are thought to traffic and regu_x0002_late the sorting of certain glycosyl-anchored proteins in the ARF6-associated pathway. Mucolipin 2 is found primarily in the plasma membrane, but is also expressed in intracellular vesicles, tubular structures and B lymphocytes. Mucolipin 2 expression in B lymphocytes and its association with Bruton’s tyrosine kinase suggests a possible role in B lymphocyte development. Additionally, defects in the mucolipin 2 gene may be associated with certain neurosensory disorders, as well as swelling of late endosomes and lysosomes.

• Structure Composition:

  Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

• Product Name Alternative:

  Mucolipin-2

• Swiss Prot:

  Q8IZK6

• Reactivity:

  Human, Rat

• Immunogen:

  Recombinant protein corresponding to human MCOLN2. The exact sequence is proprietary.

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB (1/500 - 1/1000)

• Purity:

  The antibody was purified by immunogen affinity chromatography.

• Modification:

  Unmodification

• Molecular Weight:

  ~ 80 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Recognizes endogenous levels of MCOLN2 protein.

• Applications Notes:

  Western blot analysis of MCOLN2 expression in THP1 (A) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4