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MCOLN2 polyclonal antibody

CAT: 0384-BS67768-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67768-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The mucolipins are a family of cation channel proteins designated mucolipin 1, mucolipin 2 and mucolipin 3. Mucolipin 2 is a lysosomal protein that inter_x0002_acts with the ARF6-associated pathway through co-localization with the cargo proteins CD59 and MHC1. These interactions are thought to traffic and regu_x0002_late the sorting of certain glycosyl-anchored proteins in the ARF6-associated pathway. Mucolipin 2 is found primarily in the plasma membrane, but is also expressed in intracellular vesicles, tubular structures and B lymphocytes. Mucolipin 2 expression in B lymphocytes and its association with Bruton’s tyrosine kinase suggests a possible role in B lymphocyte development. Additionally, defects in the mucolipin 2 gene may be associated with certain neurosensory disorders, as well as swelling of late endosomes and lysosomes.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Mucolipin-2
Swiss Prot
Q8IZK6
Reactivity
Human, Rat
Immunogen
Recombinant protein corresponding to human MCOLN2. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 80 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of MCOLN2 protein.
Applications Notes
Western blot analysis of MCOLN2 expression in THP1 (A) whole cell lysates.
Host or Source
Rabbit

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