DOK4 polyclonal antibody

• Background:

  DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity) . Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.

• Structure Composition:

  Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

• Product Name Alternative:

  Docking protein 4; Downstream of tyrosine kinase 4; Insulin receptor substrate 5; IRS-5; IRS5

• Swiss Prot:

  Q8TEW6

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human DOK4. The exact sequence is proprietary.

• Conjugation:

  Unconjugated

• Applications:

  WB, IF/ICC

• Dilution:

  WB (1/500 - 1/1000), IF/ICC (1/50 - 1/200)

• Purity:

  The antibody was purified by immunogen affinity chromatography.

• Modification:

  Unmodification

• Molecular Weight:

  ~ 45 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Recognizes endogenous levels of DOK4 protein.

• Applications Notes:

  Western blot analysis of DOK4 expression in HEK293T (A), HepG2 (B), rat liver (C), mouse kidney (D) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4