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IL-1R2 polyclonal antibody

CAT: 0384-BS67514-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67514-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IL-1R2 is a type I transmembrane glycoprotein that is expressed predominantly by cells of the myeloid lineage. Like IL-1R1, the extracellular domain of IL-1R2 is capable of binding to all three forms of IL-1 . Unlike IL-1R1, however, membrane-bound IL-1R2 has a short cytoplasmic tail and does not transduce signals upon binding IL-1 but rather functions as a decoy receptor to dampen IL-1 signaling . As a negative regulator of the IL-1 receptor signaling complex, research studies have also demonstrated that membrane-bound IL-1R2 undergoes regulated intramembrane proteolysis in response to pro-inflammatory molecules. This process converts the extracellular domain of IL-1R2 into a soluble decoy receptor capable of binding IL-1, limiting its capacity to elicit productive signals through membrane-bound IL-1R1 . Recent studies have demonstrated that some types of human cancers are enriched with regulatory T cells that express high levels of IL-1R2, an attribute that may contribute to their role in immunosuppression .
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
IL1RB; Interleukin-1 receptor type 2; IL-1R-2; IL-1RT-2; IL-1RT2; CD121 antigen-like family member B; CDw121b; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor type II; CD121b
Swiss Prot
P27930
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IL-1R2. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
NF-kB Signaling
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 47 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of IL-1R2 protein.
Applications Notes
Western blot analysis of IL-1R2 expression in rat lung (A), mouse spleen (B), SHSY5Y (C), Myla2059 (D), A549 (E) whole cell lysates.
Host or Source
Rabbit

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