Fetuin A polyclonal antibody

• Background:

  Fetuin A is produced by liver and secreted to plasma, and selectively concentrated in bone matrix. It is synthesized as a precursor and processed to generate 2 chains that are held together by a disulfide bond. It is a systemically acting calcification inhibitor . Reduced level of fetuin A in serum is associated with increased cardiovascular mortality in dialysis patients . Fetuin A can inhibit insulin-induced tyrosine phosphorylation of the insulin receptor tyrosine kinase and insulin receptor substrate-1 . Fetuin A deficient mice show high insulin sensitivity and high levels of serum fetuin A are associated with insulin resistance in humans .

• Structure Composition:

  Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

• Product Name Alternative:

  FETUA; Alpha-2-HS-glycoprotein; Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; Fetuin-A

• Swiss Prot:

  P02765

• Reactivity:

  Human, Mouse, Rat, Bovine, Sheep

• Immunogen:

  KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Fetuin A. The exact sequence is proprietary.

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB (1/500 - 1/1000)

• Purity:

  The antibody was purified by immunogen affinity chromatography.

• Modification:

  Unmodification

• Molecular Weight:

  ~ 55 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Recognizes endogenous levels of Fetuin A protein.

• Applications Notes:

  Western blot analysis of Fetuin A expression in PC12 (A), AML12 (B), HEK293T (C), H1792 (D) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4