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Claudin 4 polyclonal antibody

CAT: 0384-BS67454-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67454-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and junction adhesion molecule. Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-4 is not expressed in rat liver, whereas in pancreas, claudin-4 is localized to junctions of the duct epithelia and junctions of acinar cells. In the rat gut, claudin-4 displays highly restricted expression to colonic surface cells. The human claudin-4 gene maps to chromosome 7q11.23.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
CPER; CPETR1; WBSCR8; Claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein
Swiss Prot
O14493
Reactivity
Human, Mouse
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Claudin 4. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB, IHC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 22 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Claudin 4 protein.
Applications Notes
Western blot analysis of Claudin 4 expression in HCT116 (A), Panc1 (B) whole cell lysates.
Host or Source
Rabbit

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