Rad50 polyclonal antibody

CAT: 0384-BS78417-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS78417-01Size:50 µL
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Background
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
RAD50; NBSLD; RAD502; hRad50
Swiss Prot
Q92878
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human Rad50 (NP_005723.2) .
Conjugation
Unconjugated
Applications
WB, IHC, IP
Dilution
WB,1:500 - 1:2000|IHC,1:50 - 1:200|IP,1:20 - 1:50
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
154KDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Unmodification
Host or Source
Rabbit

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