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Rad50 (A708) polyclonal antibody

CAT: 0384-BS2232-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS2232-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Rad52 family members (Rad50, Rad51B/C/D, Rad52, Rad54, MRE11) mediate DNA double-strand break repair (DSBR) for DNA damage that otherwise could cause cell death, mutation or neoplastic transformation. Rad51 (RECA, BRCC5) interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of Rad51. Rad52 forms a heptameric ring that binds single-stranded DNA ends and catalyzes DNA-DNA interaction necessary for the annealing of complementary strands.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
DNA repair protein RAD50; hRAD50; RAD50
Swiss Prot
Q92878
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 670-722 of Human Rad50.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 170 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Rad50 (A708) polyclonal antibody detects endogenous levels of Rad50 protein.
Applications Notes
Western blot (WB) analysis of Rad50 (A708) polyclonal antibody at 1:500 dilution Lane1:786-O whole cell lysate (40ug) Lane2:U-87MG whole cell lysate (40ug) Lane3:SGC-7901 whole cell lysate (40ug) Lane4:SK-OVCAR3 whole cell lysate (40ug) Lane5:The Testis tissue lysate of Mouse (40ug) Lane6:The Testis tissue lysate of Rat (40ug) Lane7:C6 whole cell lysate (40ug)
Host or Source
Rabbit

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