Phospho-Nrf2 (Ser40) monoclonal antibody

• Background:

  Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

• Structure Composition:

  50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

• Product Name Alternative:

  NFE2L2; NRF2; Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor; erythroid derived 2; like 2

• Swiss Prot:

  Q16236

• Reactivity:

  Human

• Immunogen:

  A synthetic phosphopeptide corresponding to residues surrounding Ser40 of human Nrf2

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC-P

• Dilution:

  WB: 1/500-1/1000 IHC: 1/50-1/100

• Purity:

  Affinity Purified

• Modification:

  Phosphorylated

• Molecular Weight:

  Calculated MW: 68 kDa; Observed MW: 100 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Applications Notes:

  Western blot analysis of Phospho-Nrf2 in K562, Hela lysates using Phospho-Nrf2 antibody.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4