CD146 polyclonal antibody

• Background:

  CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development.

• Structure Composition:

  Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Product Name Alternative:

  CD146; MUC18

• Swiss Prot:

  P43121

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthesized peptide derived from human CD146

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC-P, ICC/IF, IP, FC

• Dilution:

  WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20 FC: 1/50-1/100

• Purity:

  Affinity Purified

• Modification:

  Unmodified

• Molecular Weight:

  Calculated MW: 72 kDa; Observed MW: 72 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Applications Notes:

  Western blot analysis of CD146 in A375 lysates; HUVEC lysates using CD146 antibody.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4