CD147 polyclonal antibody

CAT: 0384-NCP0177P-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-NCP0177P-01Size:50 µL
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Background
Basigin (EMMPRIN, CD147) is a type I integral membrane receptor protein belonging to the immunoglobulin superfamily. Basigin is a glycosylated protein with four known isoforms, of which isoform 2 is the most abundantly expressed. Multiple functions have been ascribed to Basigin; foremost among these is stimulating the secretion of extracellular matrix metalloproteinases by adjacent fibroblasts, a function which has been implicated in promoting tumor progression. Research studies have shown that Basigin is overexpressed by many tumor cells, and its expression level may correlate with tumor malignancy. A recent study identified the BASIGIN gene as a regulatory target of Slug, suggesting a role for Basigin in the process of epithelial-mesenchymal transition. Basigin has also been identified as a marker for a subset of highly suppressive regulatory T cells, and as an obligate receptor for the malarial parasite Plasmodium falciparum on human erythrocytes.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Basigin; 5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; EMMPRIN; Hepatoma-associated antigen; HAb18G; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor; TCSF; CD147; BSG; UNQ6505/PRO21383
Swiss Prot
P35613
Reactivity
Human
Immunogen
Recombinant protein of human CD147.
Conjugation
Unconjugated
Applications
WB IP IF
Dilution
WB: 1:2000~1:5000 IP 1:50 - 1:200 IF 1:100 - 1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 42 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD147 polyclonal antibody detects endogenous levels of CD147 protein.
Applications Notes
Western blot (WB) analysis of CD147 polyclonal antibody at 1:5000 dilution Lane1:A375 cell membrane lysate (10ug) Lane2:SK-OVCAR3 cell membrane lysate (4ug)
Host or Source
Rabbit

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