BMP2K polyclonal antibody

• Background :

  The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. BMP2K (BMP2 inducible kinase), also known as BIKE, is a 1,161 amino acid nuclear protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Thought to be involved in osteoblast differentiation, BMP2K catalyzes the ATP-dependent phosphorylation of bone morphogenic proteins (BMPs) ; proteins that are essential for proper cartilage and bone formation. Via its catalytic activity, BMP2K may play a role in signaling pathways that mediate bone growth and cellular differentiation. Three isoforms of BMP2K exist due to alternative splicing events.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative :

  BMP-2-inducible protein kinase; BIKe; BMP2K; BIKE; HRIHFB2017

• Swiss Prot :

  Q9NSY1

• Reactivity :

  Human

• Immunogen :

  Synthetic peptide, corresponding to Human BMP2K.

• Conjugation :

  Unconjugated

• Applications :

  WB IP

• Dilution :

  WB: 1:1000~1:2000 IP 1:50 - 1:200

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodified

• Molecular Weight :

  ~ 130 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  BMP2K polyclonal antibody detects endogenous levels of BMP2K protein.

• Applications Notes :

  Western blot (WB) analysis of BMP2K polyclonal antibody at 1:1000 dilution Lane1:A549 whole cell lysate (30ug) Lane2:MCF-7 whole cell lysate (30ug)

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4