CD206 polyclonal antibody

• Background:

  CD206, also known as macrophage mannose receptor type C (MMR or MRC1), is a type I membrane receptor protein. It is an phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  CLEC13D; CLEC13DL; MRC1L1; Macrophage mannose receptor 1; MMR; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1; CD206

• Swiss Prot:

  P22897

• Reactivity:

  Human, Rat, Mouse

• Immunogen:

  Recombinant fusion protein of human CD206.

• Conjugation:

  Unconjugated

• Related Pathways:

  Tumor-Infiltrating Immune Cell Marker Guide

• Applications:

  WB, IHC, ICC/IF, IP

• Dilution:

  WB: 1/500-1/2000 IHC: 1/100-1/300 IF/ICC: 1/100-1/300 IP: 1/50-1/100

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodified

• Molecular Weight:

  ~ 190 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CD206 polyclonal antibody detects endogenous levels of CD206 protein.

• Applications Notes:

  Western blot analysis of CD206 expression in mouse liver (A) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4