CD209 polyclonal antibody

CAT: 0384-NCP0190P-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-NCP0190P-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
DC-SIGN (CD209, CLEC4L) is a C-type lectin receptor expressed by dendritic cells (DCs) . The DC-SIGN transcript can undergo several splicing events to generate at least thirteen different transmembrane and soluble isoforms. DC-SIGN responds to a broad range of pathogens due to its ability to recognize both mannose and fructose carbohydrates, and is well studied for its role in HIV infection. Recognition of the HIV envelope glycoprotein gp120 by DC-SIGN leads to internalization of HIV by DCs and facilitates transmission of the virus to CD4+ T cells. DC-SIGN also mediates adhesion to T cells through interaction with ICAM-3, as well as transmigration across the endothelium by binding to ICAM-2. The DC-SIGN receptor can modulate TLR signaling by activating the kinase Raf-1. The closely related molecule DC-SIGNR (L-SIGN, CLEC4M) is 77% homologous to DC-SIGN and likely arose through a gene duplication event. Like DC-SIGN, DC-SIGNR binds mannose carbohydrates on the surface of pathogens. However, the expression patterns of the two receptors differ, as DC-SIGNR expression is restricted to endothelial cells of the liver, lymph node, and placenta. Murine cells contain a set of related molecules, SIGNR1-SIGNR8. Based on sequence analysis, there is no clear murine ortholog to human DC-SIGN, however SIGNR3 is the most functionally similar due to its ability to recognize both mannose and fructose structures.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
CD209 antigen; C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1 (DC-SIGN; DC-SIGN1) ; CD209
Swiss Prot
Q9NNX6
Reactivity
Human, Rat, Mouse
Immunogen
Recombinant protein of human CD209.
Conjugation
Unconjugated
Applications
IF
Dilution
IF: 1:100~1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD209 polyclonal antibody detects endogenous levels of CD209 protein.
Applications Notes
Immunofluorescence analysis of MG63 cells using CD209 pAb at dilution of 1:200 (40x lens) .
Host or Source
Rabbit

Related Products

CatalogName
BS40593-01CD209 Rabbit monoclonal antibody
NCP0190-01CD209 Recombinant Protein
BS6871-01CD200 polyclonal antibody
BS67725CD279 polyclonal antibody
NCP0370P-01CD208 polyclonal antibody
BS90224-01CD206 polyclonal antibody
NCP0326P-01CD204 polyclonal antibody
BS78331-01CD200 polyclonal antibody
BS62543CD20 polyclonal antibody
BS67769-01CD20 polyclonal antibody

Alternative Products

CatalogName
RD81865A-01CD209 Polyclonal Antibody
11-4057-25Polyclonal Antibody to CD209
APRab08279-01CD209 Rabbit Polyclonal Antibody
abx421230-01CD209 Antigen (CD209) Antibody

Popular Products