CD79A polyclonal antibody

• Background:

  Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative:

  B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein; CD79a

• Swiss Prot:

  P11912

• Reactivity:

  Rat, Mouse, Human

• Immunogen:

  Recombinant protein of human CD79A.

• Conjugation:

  Unconjugated

• Applications:

  WB IF

• Dilution:

  WB: 1:2000~1:5000 IF 1:50~1:200

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodified

• Molecular Weight:

  ~ 45 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CD79A polyclonal antibody detects endogenous levels of CD79A protein.

• Applications Notes:

  Western blot (WB) analysis of CD79A polyclonal antibody at 1:2000 dilution Lane1:C6 whole cell lysate (30ug) Lane2:CT-26 whole cell lysate (30ug) Lane3:SGC7901 whole cell lysate (30ug) Lane4:EC9706 cell membrane lysate (30ug) Lane5:MCF-7 cell membrane lysate (30ug)

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4