CD1D polyclonal antibody

• Background:

  The CD1 multigene family encodes five forms of the CD1 T cell surface glyco_x0002_protein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 mem_x0002_brane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 anti_x0002_gens are associated with b-2-Microglobulin and expressed on cortical thymo_x0002_cytes, Langerhans cells, a B cell subset and some dendritic cells. Adaptor pro_x0002_tein complexes and CD1-associated chaperones control CD1 trafficking and the development and activation of CD1-restricted T cells. CD1D is present on human intestinal epithelial cells (IEC) and exists as a b-2-Microglobulin_x0002_independent nonglycosylated form or a b-2-Microglobulin-dependent glycosy_x0002_lated form. The human CD1D gene maps to chromosome 1q23.1 and encodes a 335 amino acid protein that influences normal T cell maturation.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative:

  Antigen-presenting glycoprotein CD1d; R3G1; CD1d; CD1D

• Swiss Prot:

  P15813

• Reactivity:

  Human

• Immunogen:

  Recombinant protein of human CD1D.

• Conjugation:

  Unconjugated

• Applications:

  WB IF

• Dilution:

  WB: 1:2000~1:5000 IF 1:50~1:200

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodified

• Molecular Weight:

  ~ 55 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CD1D polyclonal antibody detects endogenous levels of CD1D protein.

• Applications Notes:

  Western blot (WB) analysis of CD1D polyclonal antibody at 1:2000 dilution Lane1:L02 cell membrane lysate (24ug) Lane2:A549 cell membrane lysate (24ug)

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4