PD-L1 (CD274) Rabbit monoclonal antibody

• Background:

  Programmed cell death ligand 1 (CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative:

  B7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1; CD274

• Swiss Prot:

  Q9NZQ7

• Reactivity:

  Human Mouse Rat

• Immunogen:

  A synthesized peptide derived from human PD-L1 (CD274)

• Conjugation:

  Unconjugated

• Applications:

  WB IHC

• Dilution:

  WB 1:100~1:500 IHC 1:50~1:100

• Purity:

  Affinity-chromatography

• Modification:

  Unmodified

• Molecular Weight:

  46kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  PD-L1 (CD274) Antibody detects endogenous levels of total PD-L1 (CD274)

• Applications Notes:

  Western blot analysis of PD-L1 (CD274) expression in Ramos cell lysate.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4