CD151 polyclonal antibody

• Background:

  CD151 (PETA-3, SFA-1) is a member of the evolutionarily conserved tetraspanin family of multipass glycoproteins (TM4SF), highlighted by four transmembrane domains, two extracellular loops, and N/C-termini that reside within the cytoplasm. Identified as the first member of the tetraspanin family to be implicated in tumorigenesis, research studies have demonstrated that CD151 participates in tumor neovascularization, tumor cell cell invasion, and cell adhesion. Furthermore, a positive correlation exists between CD151 expression levels and poor prognosis for tumors of the lung, kidney, and prostate. CD151 is localized predominantly to the plasma membrane and research studies have demonstrated that CD151 exerts its pro-tumorigenic effects, in part, through the modulation of laminin-binding integrins and oncogenic receptor tyrosine kinases, such as c-Met and EGFR.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative:

  CD151 antigen; GP27; Membrane glycoprotein SFA-1; Platelet-endothelial tetraspan antigen 3 (PETA-3) ; Tetraspanin-24 (Tspan-24) ; CD151; TSPAN24

• Swiss Prot:

  P48509

• Reactivity:

  Human, Rat, Mouse

• Immunogen:

  Recombinant protein of human CD151.

• Conjugation:

  Unconjugated

• Applications:

  IF

• Dilution:

  IF: 1:100~1:500

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodified

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CD151 polyclonal antibody detects endogenous levels of CD151 protein.

• Applications Notes:

  Immunofluorescence analysis of RAW264.7 cells using CD151 pAb at dilution of 1:200 (40x lens) .

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4