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CD226/DNAM-1 polyclonal antibody

CAT: 0384-NCP0192P-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-NCP0192P-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNAM-1/CD226 is a member of the immunoglobulin-like superfamily. It is expressed on T cells, natural killer (NK) cells, monocytes, and macrophages. It is a major activating receptor on NK cells. Engagement with its ligands Nectin-2 (CD112) and PVR (poliovirus receptor, also known as CD155) on the target cells leads to downstream activation of ERK, AKT, and PLCg2 signaling pathways that are crucial for NK activation and NK-mediated killing. LFA-1 physically associates with DNAM-1/CD226 and contributes to its signaling. Activating signal of DNAM-1/CD226 is counterbalanced by inhibitory receptors TIGIT and CD96, competing for the common ligands CD122 and PVR.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
CD226 antigen; DNAM1; DNAM-1; DNAX accessory molecule 1
Swiss Prot
Q15762
Reactivity
Human, Rat, Mouse
Immunogen
Recombinant protein of human CD226/DNAM-1.
Conjugation
Unconjugated
Applications
IF
Dilution
IF: 1:100~1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD226/DNAM-1 polyclonal antibody detects endogenous levels of CD226/DNAM-1 protein.
Applications Notes
Immunofluorescence analysis of MG63 cells using CD226/DNAM-1 pAb at dilution of 1:200 (40x lens) .
Host or Source
Rabbit

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