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MYH8 polyclonal antibody

CAT: 0384-BS61311-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61311-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Actin is a highly conserved protein that is expressed in all eukaryotic cells. Actin filaments can form both stable and labile structures, and are crucial components of microvilli and the contractile apparatus of muscle cells. Myosin is a hexamer of two heavy chains (MHC) and four light chains (MLC) that interact with Actin to generate the force for diverse cellular movements, including cytokinesis, phagocytosis and muscle contraction. MYH3 (Myosin heavy chain 3), also known as muscle embryonic Myosin heavy chain or SMHCE, is a 1,940 amino acid that localizes to the thick filaments of myofibrils. While highly expressed in fetal skeletal muscle, MYH3 is barely detectable in adult skeletal muscle. Defects in the gene encoding MYH3, which maps to human chromosome 17p13.1, are the cause of distal arthrogryposis type 2B (DA2B) .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Myosin-8; Myosin heavy chain 8; Myosin heavy chain, skeletal muscle, perinatal; MyHC-perinatal; MYH8
Swiss Prot
P13535
Reactivity
Human, Rat, Mouse
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MYH8.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 223 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
MYH8 polyclonal antibody detects endogenous levels of MYH8 protein.
Applications Notes
Western blot analysis of MYH8 expression in HEK293T (A), H1792 (B), U2OS (C), rat testis (D) whole cell lysates.
Host or Source
Rabbit

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