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CD90 monoclonal antibody

CAT: 0384-MB65821-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB65821-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The Thy1/CD90 cell surface antigen is a GPI-anchored, developmentally regulated protein involved in signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and fibrosis. Thy1/CD90 is highly expressed on the surface of adult neurons and is thought to play a role in modulating adhesive and migratory events, such as neurite extension. Decreased Thy1/CD90 mRNA and protein expression is associated with the development of epithelial ovarian cancer, suggesting a role as a putative tumor suppressor gene of human ovarian cancer. Research studies indicate that Thy1/CD90 knockout mice have impaired cutaneous immune responses and abnormal retinal development. Thy1/CD90 is epigenetically regulated or deregulated in some disease states, such as pulmonary fibrosis. The potentially reversible hypermethylation of the Thy1/CD90 promoter offers the possibility of novel therapeutic options in this disease.
CAS Number
9007-83-4
Structure Composition
Purified antibody in PBS with 0.05% sodium azide.
Product Name Alternative
Thy-1 membrane glycoprotein; CDw90; Thy-1 antigen; CD90
Swiss Prot
P04216
Reactivity
Human
Immunogen
Purified recombinant fragment of human THY1 expressed in E. Coli.
Conjugation
Unconjugated
Applications
WB, IHC-P, ICC/IF, ELISA
Dilution
WB: 1/500-1/1000 IHC: 1/100-1/200 IF: 1/50-1/200 ELISA: 1/10000
Purity
The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 18 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes human CD90
Host or Source
Mouse

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