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GSK3β (S13) polyclonal antibody

CAT: 0384-BS1157-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1157-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B
Swiss Prot
P49841
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human GSK3β.
Conjugation
Unconjugated
Related Pathways
PI3K AKT signaling, Hedgehog Signaling, Hypoxia Signaling, Translational Contral Regulation of elF2, Regulation of Microtubule Dynamics, Inhibition of Apoptosis, Insulin &Glucose Signaling, Cell Cycle Control G1 S Checkpoint, Adherens Junction signaling, MTOR signaling
Applications
WB IF IP
Dilution
WB: 1:500~1:1000 IF: 1:50~200 IP: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 46 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
GSK3β (S13) polyclonal antibody detects endogenous levels of GSK3β protein.
Applications Notes
Western blot (WB) analysis of GSK3β (S13) polyclonal antibody at 1:1000 dilution Lane1:The Spleen tissue lysate of Mouse (40ug) Lane2:The Brain tissue lysate of Rat (40ug) Lane3:U-87MG whole cell lysate (40ug) Lane4:A549 whole cell lysate (40ug)
Host or Source
Rabbit

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