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LDHA polyclonal antibody

CAT: 0384-BS6179-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS6179-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The lactate dehydrogenase family (LDH) catalyzes the final step of anaerobic glycolysis, the conversion of L-lactate and NAD to pyruvate and NADH. The LDH family consists of three members, LDH-A, LDH-B, and LDH-C, all of which form tetramers consisting four subunits. However, each family member displays a specific tissue distribution pattern with LDH-A and LDH-B predominant in several tissues, specifically LDH-A in muscle and LDH-B in heart, while LDH-C expression is confined to the testis and sperm. LDHs function as powerful markers for germ cell tumors. The genes encoding human LDH-A and LDH-C map to chromosome 11, while the human LDH-B gene maps to chromosome 12. Deficiency in the LDH-A gene is linked to exertional myoglobinuria.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cell proliferation-inducing gene 19 protein; GSD11; L lactate dehydrogenase A chain; L-lactate dehydrogenase A chain; l7R2; Lactate dehydrogenase 1; A chain; Lactate dehydrogenase A; Lactate dehydrogenase A4; Lactate dehydrogenase M; LDH A; LDH M; LDH muscle subunit; LDH muscle subunit; M LDH; LDH-A; LDH-M; LDH1; ldha; LDHA; LDHM; OTTMUSP00000017774; PIG19; Proliferation-inducing gene 19; Renal carcinoma antigen NY-REN-59
Swiss Prot
P00338
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length protein of human LDHA.
Conjugation
Unconjugated
Related Pathways
Warburg Effect, Glutamine Metabolism, AMPK Signaling Pathway
Applications
WB, IHC, IF/ICC
Dilution
WB,1:500 - 1:2000|IHC,1:10 - 1:100|IF/ICC,1:10 - 1:100
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 37 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
LDHA polyclonal antibody detects endogenous levels of LDHA protein.
Applications Notes
Western blot analysis of LDHA expression in MCF7 (A), Jurkat (B), NIH3T3 (C), mouse skeletal muscle (D) whole cell lysates.
Host or Source
Rabbit

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