TRAF6 (H154) polyclonal antibody

CAT: 0384-BS3684-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS3684-01Size:50 µL
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Background
Tumor necrosis factor receptor-associated factor 6 (TRAF6) regulates adaptive immunity, innate immunity and bone metabolism. TRAF6 is a ubiquitin (Ub) ligase that mediates the activation of protein kinases, such as transforming growth factor beta-activated kinase (TAK1) and IκB kinase (IKK), by catalyzing the formation of a unique polyubiquitin chain linked through Lys 63 of Ub. TRAF6 is essential for activating NFκB signaling pathway in response to interleukin-1 and Toll-like receptor ligands. The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination and activating NFκB signaling pathway. TRAF6 interacts with various protein kinases including IRAK1/IRAK, SRC and PKCζ, which provides a link between distinct signaling pathways.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85; TRAF6; RNF85; TRAF 6; TRAF-6
Swiss Prot
Q9Y4K3
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 122-170 of Human TRAF6.
Conjugation
Unconjugated
Related Pathways
Toll-like Receptor signaling, Death Receptor Signaling
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 58 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TRAF6 (H154) polyclonal antibody detects endogenous levels of TRAF6 protein.
Applications Notes
Western blot (WB) analysis of TRAF6 (H154) polyclonal antibody at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:Mouse kidney tissue lysate Lane3:Rat kidney tissue lysate Lane4:HEK293T cell lysate
Host or Source
Rabbit

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