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AIF-M1 (Y85) polyclonal antibody

CAT: 0384-BS2407-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS2407-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF) . Like the critical molecules, cytochrome c and caspase 9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase 9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli. AIF is highly conserved between human and mouse and widely expressed.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Apoptosis-inducing factor 1, mitochondrial; Programmed cell death protein 8; AIFM1; AIF; PDCD8
Swiss Prot
O95831
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 61-110 of Human AIF-M1.
Conjugation
Unconjugated
Related Pathways
Regulation of Apoptosis, Mitochondrial Control of Apoptosis
Applications
WB IHC IF
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 67 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
AIF-M1 (Y85) polyclonal antibody detects endogenous levels of AIF-M1 protein.
Applications Notes
Western blot (WB) analysis of AIF-M1 (Y85) polyclonal antibody at 1:500 dilution Lane1:The liver tissue lysate of Mouse (39ug) Lane2:MCF-7 whole cell lysate (40ug) Lane3:H9C2 whole cell lysate (40ug)
Host or Source
Rabbit

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