CD305 polyclonal antibody

• Background :

  LAIR-1 is an inhibitory receptor that belongs to the Immunoglobulin superfamily. It has one extracellular Ig-like domain and an intracellular C-terminus with two ITIM (immunoreceptor tyrosine-based inhibitory motif) domains. It is found on peripheral mononuclear cells, including NK, T, and B cells, and is thought to play a negative regulatory role on the cytolytic function of these cells through signaling through collagen ligation. LAIR1 has been noted to be upregulated in renal cell carcinoma, and may play a role in expansion of Th17 cell populations in collagen-rich environments, such as in graft rejection tissue.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative :

  Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; hLAIR1; LAIR1

• Swiss Prot :

  Q6GTX8

• Reactivity :

  Human

• Immunogen :

  Recombinant protein of human CD305.

• Conjugation :

  Unconjugated

• Applications :

  WB IF

• Dilution :

  WB: 1:1000~1:2000 IF: 1:100~1:500

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodified

• Molecular Weight :

  ~ 46 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  CD305 polyclonal antibody detects endogenous levels of CD305 protein.

• Applications Notes :

  Western blot (WB) analysis of CD305 polyclonal antibody at 1:1000 dilution Lane1:THP-1 whole cell lysate (30ug Lane2:L02 cell membrane lysate (24ug) Lane3:MCF-7 cell membrane lysate (24ug)

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4