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CD158a polyclonal antibody

CAT: 0384-NCP0282P-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-NCP0282P-01Size:50 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NKAT (NK-associated transcripts) gene products, known as killer immuno_x0002_globulin-like receptors or KIRs, downregulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. This family of receptors is characterized by an extracellular region with two to three immunoglobulin-superfamily domains and a cytoplasmic domain with an antigen receptor activation motif (ARAM) . KIRs and other inhibitory receptors also possess a common cytoplasmic sequence (I/VxYxxL/V) known as an ITIM (immunoreceptor tyrosine-based inhibitory motif) . The human inhibitory natural killer cell immunoglobulin-like receptor 2DL1, also designated KIR2DL1, CL-42, NKAT1, P58.1 or CD158a long form, is a 348 amino acid type I transmembrane protein. KIR2DL1 can bind human leukocyte antigen-C (HLA-C) via both polar and hydrophobic interac_x0002_tions through Met 44 in a binding pocket that coordinates Lys 80 of HLA-C.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Killer cell immunoglobulin-like receptor 2DL1; CD158 antigen-like family member A; Natural killer-associated transcript 1; NKAT-1; p58 natural killer cell receptor clones CL-42/47.11; p58 NK receptor CL-42/47.11; p58.1 MHC class-I-specific NK receptor; CD158a; KIR2DL1; CD158A; NKAT1
Swiss Prot
P43626
Reactivity
Human, Mouse
Immunogen
Recombinant protein of human CD158a.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:5000~1:10000 IF: 1:100~1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 49 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD158a polyclonal antibody detects endogenous levels of CD158a protein.
Applications Notes
Western blot (WB) analysis of CD158a polyclonal antibody at 1:5000 dilution Lane1:The Heart tissue lysate of Mouse (15ug) Lane2:L02 cell membrane lysate (24ug) Lane3:MCF-7 cell membrane lysate (24ug)
Host or Source
Rabbit

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