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PPM1D mouse monoclonal antibody

CAT: 0384-MB4031-01Size: 25 µLDry Ice: NoHazardous: No
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CAT#:0384-MB4031-01Size:25 µL
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Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Protein phosphatase 1D; EC:3.1.3.16 ; Protein phosphatase 2C isoform delta (PP2C-delta) ; Protein phosphatase magnesium-dependent 1 delta; p53-induced protein phosphatase 1; PPM1D; WIP1; 9606 NCBI; Homo sapiens (Human)
Swiss Prot
O15297
Reactivity
Human, Mouse, Rat
Immunogen
Human recombinant protein fragment corresponding to amino acids 1-375 of human PPM1D (NP_003611) produced in E.coli.
Conjugation
Unconjugated
Applications
WB
Dilution
WB 1:500~2000
Purity
The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 65 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG1
Applications Notes
Western blot (WB) analysis of PPM1D mouse monoclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate (30ug) Lane2:Hela whole cell lysate (30ug)
Host or Source
Mouse

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