Carbazomycin B

• Description:

  Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC50 Of 1.5 µM[1]sup>[2]sup>[3]sup>[4].

• UNSPSC:

  12352005

• Target:

  Antibiotic; Bacterial; Lipoxygenase

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/carbazomycin-b.html

• Smiles:

  OC1=C (C (C) =C (C) C2=C1C3=C (C=CC=C3) N2) OC

• Molecular Formula:

  C15H15NO2

• Molecular Weight:

  241.29

• References & Citations:

  [1]Sakano K, et al. New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties. J Antibiot (Tokyo) . 1980;33 (7) :683-689. |[2]Naid T, et al. Carbazomycins C, D, E and F, minor components of the carbazomycin complex. J Antibiot (Tokyo) . 1987;40 (2) :157-164. |[3]Hook DJ, et al. Identification of the inhibitory activity of carbazomycins B and C against 5-lipoxygenase, a new activity for these compounds. J Antibiot (Tokyo) . 1990 Oct;43 (10) :1347-8. |[4]Yamasaki K, Kaneda M, Watanabe K, et al. New antibiotics, carbazomycins A and B. III. Taxonomy and biosynthesis. J Antibiot (Tokyo) . 1983;36 (5) :552-558.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  75139-38-7