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D-65476

CAT: 0804-HY-112378Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-112378Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-65476 is an inhibitor of type III receptor tyrosine kinase (Flt3) . In the absence of IL-3, D-65476 inhibits the proliferation of TEL-Flt3 transfected BA/F3 cells (IC50= 0.2 μM), which can be used in the study of Flt3-driven leukemia[1].
CAS Number
249762-74-1
UNSPSC
12352005
Target
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/d-65476.html
Smiles
O=C(CCC)OC1=CC2=C(NC(C(C3=CC4=C(N3)C=CC=C4)=O)=C2)C=C1
Molecular Formula
C21H18N2O3
Molecular Weight
346.38
References & Citations
[1]Teller S, et al. Bis (1H-2-indolyl) -1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3. Leukemia. 2002;16 (8) :1528-1534.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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