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Bucillamine

CAT: 0804-HY-118530-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118530-01Size:25 mg
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Description
Bucillamine (SA96) is an orally active and potent sulfhydryl donor and antioxidant. Bucillamine is also an antirheumatic agent with antiangiogenic properties. Bucillamine can protect against Ischemia/reperfusion (I/R) injury in high-risk organ transplants. Bucillamine inhibits the production of VEGF. Bucillamine can be used for the research of choroidal neovascularization (CNV) and rheumatoid arthritis (RA) [1][2].
CAS Number
65002-17-7
Product Name Alternative
SA96; Thiobutarit
UNSPSC
12352211
Hazard Statement
H302-H318-H410
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bucillamine.html
Purity
98.87
Solubility
H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
SC[C@@H](C(O)=O)NC(C(C)(S)C)=O
Molecular Formula
C7H13NO3S2
Molecular Weight
223.31
Precautions
P264-P270-P273-P280-P305+P351+P338-P330-P391-P501
References & Citations
[1]Amersi F, et al. Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury. Proc Natl Acad Sci U S A. 2002 Jun 25;99 (13) :8915-20.|[2]Yanagi Y, et al. Subconjunctival administration of bucillamine suppresses choroidal neovascularization in rat. Invest Ophthalmol Vis Sci. 2002 Nov;43 (11) :3495-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 4

Chemical Information

Bucillamine

Bucillamine is an organic molecular entity.

CAS Number65002-17-7
PubChem CID656604
IUPAC Name(2R)-2-[(2-methyl-2-sulfanylpropanoyl)amino]-3-sulfanylpropanoic acid
Molecular FormulaC7H13NO3S2
Molecular Weight223.3
XLogP0.4
Topological Polar Surface Area68.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count13
Formal Charge0
Complexity218
SMILES
CC(C)(C(=O)N[C@@H](CS)C(=O)O)S
InChI
InChI=1S/C7H13NO3S2/c1-7(2,13)6(11)8-4(3-12)5(9)10/h4,12-13H,3H2,1-2H3,(H,8,11)(H,9,10)/t4-/m0/s1
InChIKey
VUAFHZCUKUDDBC-BYPYZUCNSA-N
Chemical Structure
2D Structure
2D structure of Bucillamine
CAS: 65002-17-7
CID: 656604
Formula: C7H13NO3S2
MW: 223.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight223.3
XLogP30.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass223.03368562
Monoisotopic Mass223.03368562
Topological Polar Surface Area68.4 Ų
Heavy Atom Count13
Formal Charge0
Complexity218
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3615987-01Bucillamine
162960Bucillamine-d6

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