SIRP alpha Recombinant Rabbit Monoclonal Antibody [JE36-20]

SIRP alpha Recombinant Rabbit Monoclonal Antibody [JE36-20]

• Description: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB1. Binds PTK2B.
• Product Name Alternative: Signal regulatory protein alpha type 1 antibody Bit antibody Brain Ig like molecule with tyrosine based activation motifs antibody Brain Ig-like molecule with tyrosine-based activation motifs antibody Brain immunoglobulin like molecule with tyrosine based activation motifs antibody CD172 antigen like family member A antibody CD172 antigen-like family member A antibody CD172a antibody CD172a antigen antibody Inhibitory receptor SHPS-1 antibody Macrophage fusion receptor antibody MFR antibody MYD 1 antibody Myd 1 antigen antibody MyD-1 antigen antibody p84 antibody Protein tyrosine phosphatase non receptor type substrate 1 antibody PTPNS1 antibody SHP substrate 1 antibody SHPS-1 antibody SHPS1 antibody SHPS1_HUMAN antibody Signal regulatory protein alpha 2 antibody Signal regulatory protein alpha 3 antibody Signal regulatory protein alpha antibody Signal regulatory protein alpha type 2 antibody Signal-regulatory protein alpha-1 antibody Signal-regulatory protein alpha-2 antibody Signal-regulatory protein alpha-3 antibody SIRP antibody Sirp-alpha-1 antibody Sirp-alpha-2 antibody Sirp-alpha-3 antibody SIRPA antibody SIRPalpha antibody SIRPalpha1 antibody SIRPalpha2 antibody SIRPalpha3 antibody Tyrosine phosphatase SHP substrate 1 antibody Tyrosine protein phosphatase non receptor type substrate 1 antibody Tyrosine-protein phosphatase non-receptor type substrate 1 antibody
• Abbreviation: Tyrosine-protein phosphatase non-receptor type substrate 1 SHP substrate 1; SHPS-1 Brain Ig-like molecule with tyrosine-based activation motifs (Bit) CD172 antigen-like family member A Inhibitory receptor SHPS-1 Macrophage fusion receptor MyD-1 antigen Signal-regulatory protein alpha-1 (Sirp-alpha-1) Signal-regulatory protein alpha-2 (Sirp-alpha-2) Signal-regulatory protein alpha-3 (Sirp-alpha-3) p84 CD172a SIRPA BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
• CAS Number: 9000-83-3
• Swiss Prot: P78324 Human, P97797 Mouse, P97710 Rat
• Cellular Locus: Membrane
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human SIRP alpha aa 395-504 (Cytoplasmic).
• Isotype: IgG
• Clone: JE36-20
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, FC
• Positive Control: THP-1 cell lysate, HL-60 cell lysate, mouse brain tissue lysate, human lymph node tissue, human spleen tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000 ;IHC-P: 1:1,000 ;FC: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 55 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes