Cefadroxil-d4 (hydrate)

Cefadroxil-d4 (hydrate) is the deuterium labeled Cefadroxil hydrate. Cefadroxil hydrate is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil hydrate inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil hydrate is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil hydrate has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain[1][2][3][4][5][6][7][8].

1426174-38-0

BL-S 578-d4 (hydrate)

12352005

Antibiotic; Bacterial; EAAT; Isotope-Labeled Compounds

Isotope-Labeled Compounds

Anti-infection; Membrane Transporter/Ion Channel; Others

Infection; Neurological Disease

10 mM in DMSO

OC(C1=C(C)CS[C@@]([C@@H]2NC([C@@H](C3=C([2H])C([2H])=C(C([2H])=C3[2H])O)N)=O)([H])N1C2=O)=O.O

C16H15D4N3O6S

385.43

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Buck RE, et al. Cefadroxil, a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1977 Feb;11 (2) :324-30.|[3]Posada MM, et al. Relevance of PepT1 in the intestinal permeability and oral absorption of cefadroxil. Pharm Res. 2013 Apr;30 (4) :1017-25.|[4]Hu Y, et al. Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice. Biochem Pharmacol. 2016 May 1;107:81-90.|[5]Han CJ, et al. Antinociceptive effects of cefadroxil and ceftriaxone in experimental animal models of pain. Neuro Endocrinol Lett. 2023 Jul 28;44 (5) :309-320.|[6]Tan Z, et al. Physiologically Based Pharmacokinetic Modeling of Cefadroxil in Mouse, Rat, and Human to Predict Concentration-Time Profile at Infected Tissue. Front Pharmacol. 2021 Dec 23;12:692741.|[7]Chisholm DR, et al. Therapeutic efficacy of cefadroxil and cephalexin for pneumonia in a rat test model. Antimicrob Agents Chemother. 1986 Jul;30 (1) :105-9. |[8]Chen X, et al. Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study. Biochem Pharmacol. 2017 May 1;131:89-97.

Room temperature

Isotope-Labeled Compounds

No Development Reported