Butylphthalide-d3

• Description:

  Butylphthalide-d3 is the deuterium labeled Butylphthalide. Butylphthalide (3-n-Butylphthalide), an anti-cerebral-ischemia agent, is first isolated from the seeds of celery and showes efficacy in animal models of stroke.

• Product Name Alternative:

  3-n-Butylphthalide-d3; 3-Butylphthalide-d3

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Others

• Field of Research:

  Neurological Disease

• Purity:

  99.81

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1OC(CCCC([2H])([2H])[2H])C2=C1C=CC=C2

• Molecular Formula:

  C12H11D3O2

• Molecular Weight:

  193.26

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Cui LY, et al. Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial. Chin Med J (Engl) . 2013;126 (18) :3405-10.|[3]Zhao W, et al. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014 Apr 1;9 (7) :719-26.|[4]Wang X, et al. Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents. Org Biomol Chem. 2014 Aug 21;12 (31) :5995-6004.|[5]Wang F, et al. Improvement of cognitive deficits in SAMP8 mice by 3-n-butylphthalide. Neurol Res. 2014 Mar;36 (3) :224-33.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported