Ropinirole

CAT: 0804-HY-B0623-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-B0623-01Size:25 mg

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Description

Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease[1][2].

CAS Number

91374-21-9

Product Name Alternative

SKF 101468

UNSPSC

12352005

Hazard Statement

H302-H412

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ropinirole.html

Purity

99.42

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C(CCN(CCC)CCC)=CC=C2)C1

Molecular Formula

C16H24N2O

Molecular Weight

260.37

Precautions

P264-P270-P273-P330-P501

References & Citations

[1]Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38 (1) : p. 147-54.|[2]Mavrikaki M, et al. Ropinirole regulates emotionality and neuronal activity markers in the limbic forebrain. Int J Neuropsychopharmacol. 2014 Dec;17 (12) :1981-93.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

D2 Receptor; D3 Receptor; D4 Receptor

Chemical Information

Ropinirole

Ropinirole is a member of indolones and a tertiary amine. It has a role as a central nervous system drug, an antiparkinson drug, a dopamine agonist and an antidyskinesia agent.

CAS Number	91374-21-9
PubChem CID	5095
IUPAC Name	4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one
Molecular Formula	C16H24N2O
Molecular Weight	260.37
XLogP	2.7
Topological Polar Surface Area	32.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	7
Heavy Atom Count	19
Formal Charge	0
Complexity	286

SMILES

CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1

InChI

InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)

InChIKey

UHSKFQJFRQCDBE-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 91374-21-9

CID: 5095

Formula: C16H24N2O

MW: 260.37

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	260.37
XLogP3	2.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	7
Exact Mass	260.188863393
Monoisotopic Mass	260.188863393
Topological Polar Surface Area	32.3 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	286
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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MBS385683-01	Ropinirole
B2129-5.1	Ropinirole HCl
TRC-R641000-25MG	Ropinirole Hydrochloride
R2999-20-01	Ropinirole, Hydrochloride
164129	Ethyl Ropinirole
A11915-250	Ropinirole 250mg
A11915-50	Ropinirole 50mg
464813-01	Ropinirole Aldehyde

Ropinirole

Chemical Information

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