Ropinirole

• Description:

  Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease[1][2].

• Product Name Alternative:

  SKF 101468

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H412

• Target:

  Dopamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ropinirole.html

• Purity:

  99.42

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1NC2=C(C(CCN(CCC)CCC)=CC=C2)C1

• Molecular Formula:

  C16H24N2O

• Molecular Weight:

  260.37

• Precautions:

  P264-P270-P273-P330-P501

• References & Citations:

  [1]Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38 (1) : p. 147-54.|[2]Mavrikaki M, et al. Ropinirole regulates emotionality and neuronal activity markers in the limbic forebrain. Int J Neuropsychopharmacol. 2014 Dec;17 (12) :1981-93.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  D2 Receptor; D3 Receptor; D4 Receptor

• CAS Number:

  [91374-21-9]