Amantadine

• UNSPSC Description:

  Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].

• Target Antigen:

  Apoptosis; Bcl-2 Family; CDK; Influenza Virus; Orthopoxvirus; SARS-CoV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Apoptosis;Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/amantadine.html

• Purity:

  99.90

• Solubility:

  DMSO : 6.48 mg/mL (ultrasonic;warming;adjust pH to 4 with 1 M HCL;heat to 60°C)

• Smiles:

  NC12C[C@H]3C[C@@H](C2)C[C@@H](C1)C3

• Molecular Weight:

  151.253

• References & Citations:

  [1]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.|[2]Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099.|[3]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. |[4]Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. |[5]Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85.|[6]Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910.SSRN. 2024 Aug 7.|Chem Phys Lipids. 2024 May 11:262:105397.|Int J Nanomedicine. 2019 Nov 27;14:9217-9234.|Signal Transduct Target Ther. 2021 Mar 27;6(1):134.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  Launched

• CAS Number:

  768-94-5