Levofloxacin (hydrochloride)

Levofloxacin hydrochloride is an orally active antibiotic. Levofloxacin inhibits DNA gyrase and topoisomerase IV activity, inducing Apoptosis. Levofloxacin hydrochloride has antibacterial activity against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride exhibits anticancer activity against lung cancer. Levofloxacin hydrochloride has anti-acnegenic, anxiogenic, and analgesic effects. Levofloxacin hydrochloride shortens sleep duration in mice. Levofloxacin hydrochloride can be used in the research of infectious diseases (such as tuberculosis, chronic periodontitis, bacterial infections associated with stable COPD, and BK viremia) and lung cancer[1][2][3][4][5][6][7][8][9][10].

177325-13-2

(-) -Ofloxacin (hydrochloride)

12352005

H302, H317, H334, H361, H362

Antibiotic; Apoptosis; Bacterial; DNA/RNA Synthesis; Orthopoxvirus; Topoisomerase

Reference compound

Anti-infection; Apoptosis; Cell Cycle/DNA Damage

COVID-19-anti-virus

Cancer; Infection; Neurological Disease

https://www.medchemexpress.com/levofloxacin-hydrochloride.html

98.0

H2O : 20 mg/mL (ultrasonic; warming; heat to 60°C)

[H]Cl.O=C(C(C1=O)=CN2[C@@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O

C18H21ClFN3O4

397.83

H302, H317, H334, H361, H362

[1]Drlica K, et al. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61 (3) :377-92.|[2]Smee DF, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57 (1-2) :41-52.|[3]Rand A, et al. Effect of levofloxacin on some body tissues in mice. Effect of levofloxacin on some body tissues in mice. Iraqi Journal of Veterinary Sciences, 2021. |[4]JI B, et al. In vitro and in vivo activities of levofloxacin against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1995 Jun;39 (6) :1341-4. |[5]Siva R, et al. Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial. Int J Chron Obstruct Pulmon Dis. 2014 Feb 7;9:179-86.|[6]Pradeep AR, et al. Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. J Investig Clin Dent. 2015 Aug;6 (3) :170-8. |[7]Lee BT, et al. Efficacy of levofloxacin in the treatment of BK viremia: a multicenter, double-blinded, randomized, placebo-controlled trial. Clin J Am Soc Nephrol. 2014 Mar;9 (3) :583-9. |[8]Ishida H, et al. In vitro and in vivo activities of levofloxacin against biofilm-producing Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1998 Jul;42 (7) :1641-5. |[9]Song M, et al. Antibiotic drug levofloxacin inhibits proliferation and induces apoptosis of lung cancer cells through inducing mitochondrial dysfunction and oxidative damage. Biomed Pharmacother. 2016 Dec;84:1137-1143. |[10]Erden BF, et al. Antidepressant, anxiogenic, and antinociceptive properties of levofloxacin in rats and mice. Pharmacol Biochem Behav. 2001 Mar;68 (3) :435-41.

Room Temperature

4°C (Powder, sealed storage, away from moisture)

Reference compound1

Launched

Topoisomerase