Dapoxetine-d6

• Description :

  Dapoxetine-d6 is the deuterium labeled Dapoxetine[1]. Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI) . Dapoxetine can be used for the research of premature ejaculation (PE) [2].

• CAS Number :

  [1132642-58-0]

• UNSPSC :

  12352005

• Target :

  Serotonin Transporter

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Solubility :

  10 mM in DMSO

• Smiles :

  [2H]C([2H])([2H])N(C([2H])([2H])[2H])[C@H](C1=CC=CC=C1)CCOC2=CC=CC3=C2C=CC=C3

• Molecular Formula :

  C21H17D6NO

• Molecular Weight :

  311.45

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Muammer Kendirci, et al. Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Ther Clin Risk Manag. 2007 Jun;3 (2) :277-89.|[3]Rabab H Sayed, et al. Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins. Toxicol Appl Pharmacol. 2016 Nov 15;311:52-60.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported