Ramipril-d5

• Description :

  Ramipril-d5 is the deuterium labeled Ramipril. Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.

• CAS Number :

  [1132661-86-9]

• Product Name Alternative :

  HOE-498-d5

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Angiotensin-converting Enzyme (ACE) ; Apoptosis; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease; Others

• Field of Research :

  Cardiovascular Disease

• Purity :

  99.9

• Solubility :

  DMSO : 100 mg/mL (ultrasonic; warming)

• Smiles :

  [2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1CC[C@@H](C(OCC)=O)N[C@@H](C)C(N2[C@]3([H])[C@](CCC3)([H])C[C@H]2C(O)=O)=O

• Molecular Formula :

  C23H27D5N2O5

• Molecular Weight :

  421.54

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Raasch, W., et al., Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR. J Hypertens, 2004. 22 (3) : p. 611-8.|[3]Stevens, B.R., M.I. Phillips, and A. Fernandez, Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp Biochem Physiol C, 1988. 91 (2) : p. 493-7.|[4]Kohlstedt, K., et al., Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res, 2004. 94 (1) : p. 60-7.|[5]Ceconi, C., et al., Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis: in vitro and in vivo studies. Cardiovasc Drugs Ther, 2007. 21 (6) : p. 423-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported