Ramipril

• Description :

  Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.

• Product Name Alternative :

  HOE-498

• UNSPSC :

  12352005

• Hazard Statement :

  H360

• Target :

  Angiotensin-converting Enzyme (ACE) ; Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cardiovascular Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ramipril.html

• Purity :

  99.33

• Solubility :

  DMSO : ≥ 100 mg/mL|H2O : 1 mg/mL (ultrasonic)

• Smiles :

  O=C([C@@H]1C[C@@](CCC2)([H])[C@@]2([H])N1C([C@@H](N[C@H](C(OCC)=O)CCC3=CC=CC=C3)C)=O)O

• Molecular Formula :

  C23H32N2O5

• Molecular Weight :

  416.51

• Precautions :

  H360

• References & Citations :

  [1]Raasch, W., et al., Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR. J Hypertens, 2004. 22 (3) : p. 611-8.|[2]Stevens, B.R., M.I. Phillips, and A. Fernandez, Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp Biochem Physiol C, 1988. 91 (2) : p. 493-7.|[3]Kohlstedt, K., et al., Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res, 2004. 94 (1) : p. 60-7.|[4]Ceconi, C., et al., Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis: in vitro and in vivo studies. Cardiovasc Drugs Ther, 2007. 21 (6) : p. 423-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [87333-19-5]