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Nimodipine-d7

CAT: 0804-HY-B0265SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0265SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nimodipine-d7 is the deuterium labeled Nimodipine. Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders[1].
CAS Number
1246815-36-0
Product Name Alternative
BAY-e 9736-d7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Calcium Channel; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Cardiovascular Disease; Cancer
Purity
99.35
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=C(C)NC(C)=C(C(OC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCOC
Molecular Formula
C21H19D7N2O7
Molecular Weight
425.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Langley, M.S., et al. Nimodipine. Drugs 37, 669–699 (1989) .|[3] Marbacher S, et al. Prevention of delayed cerebral vasospasm by continuous intrathecal infusion of glyceroltrinitrate and nimodipine in the rabbit model in vivo. Intensive Care Med. 2008;34 (5) :932-938.|[4]Honn KV, et al. Inhibition of tumor cell-platelet interactions and tumor metastasis by the calcium channel blocker, nimodipine. Clin Exp Metastasis. 1984;2 (1) :61-72.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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