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Hydrochlorothiazid-13C, d2

CAT: 0804-HY-B0252S1Size: 2.5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0252S1Size:2.5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hydrochlorothiazid-13C, d2 is the 13C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].
CAS Number
1190006-03-1
Product Name Alternative
HCTZ-13C, d2
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Potassium Channel; TGF-beta/Smad
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Others; Stem Cell/Wnt; TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Purity
98.64
Solubility
10 mM in DMSO
Smiles
O=S1(C2=CC(S(N)(=O)=O)=C(Cl)C=C2N[13C]([2H])([2H])N1)=O
Molecular Formula
C6 13CH6D2ClN3O4S2
Molecular Weight
300.74
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.|[2]Duarte, J.D. and R.M. Cooper-DeHoff, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther, 2010. 8 (6) : p. 793-802.|[3]Jinghong Luo, et al. Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats. Cardiovasc Ther. 2017 Apr;35 (2) .|[4]Magdy M Abdelquader, et al. Inhibition of Co-Crystallization of Olmesartan Medoxomil and Hydrochlorothiazide for Enhanced Dissolution Rate in Their Fixed Dose Combination. AAPS PharmSciTech. 2018 Dec 17;20 (1) :3.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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