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Didanosine-d2

CAT: 0804-HY-B0249SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0249SSize:1 Each
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Description
Didanosine-d2 is the deuterium labeled Didanosine. Didanosine (Videx) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
UNSPSC
12352005
Target
HIV; Isotope-Labeled Compounds; Reverse Transcriptase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1CC[C@H](N2C([2H])=NC3=C2N=C([2H])N=C3O)O1
Molecular Formula
C10H10D2N4O3
Molecular Weight
238.24
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Knupp, C.A., et al., Pharmacokinetics of didanosine in patients with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex. Clin Pharmacol Ther, 1991. 49 (5) : p. 523-35.|[3]Bissuel, F., et al., Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy. J Intern Med, 1994. 235 (4) : p. 367-71.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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