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Allopurinol-d2

CAT: 0804-HY-B0219SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0219SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Allopurinol-d2 is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM) . Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].
CAS Number
916979-34-5
UNSPSC
12352005
Hazard Statement
H301, H317
Target
Isotope-Labeled Compounds; Xanthine Oxidase
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Purity
99.36
Solubility
10 mM in DMSO|H2O : 1mg/mL (ultrasonic; adjust pH to 11 with NaOH)
Smiles
O=C1C2=C(NN=C2[2H])NC([2H])=N1
Molecular Formula
C5H2D2N4O
Molecular Weight
138.12
Precautions
H301, H317
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58 (1) :87-114.|[3]Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5 (5) :469-472.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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