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Ivabradine

CAT: 0804-HY-B0162Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0162Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If) . Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity[1][2][3][4].
CAS Number
155974-00-8
UNSPSC
12352005
Target
HCN Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ivabradine.html
Purity
99.93
Solubility
10 mM in DMSO
Smiles
O=C1N(CCCN(C[C@@H]2C3=CC(OC)=C(OC)C=C3C2)C)CCC4=CC(OC)=C(OC)C=C4C1
Molecular Formula
C27H36N2O5
Molecular Weight
468.59
References & Citations
[1]Tardif JC, et al. Efficacy of ivabradine, a new selective I (f) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J. 2005 Dec;26 (23) :2529-36.|[2]Mulder P, et al. Heart rate slowing for myocardial dysfunction/heart failure. Adv Cardiol. 2006;43:97-105.|[3]Cavalcante TMB, et al. Ivabradine possesses anticonvulsant and neuroprotective action in mice. Biomed Pharmacother. 2019 Jan;109:2499-2512.|[4]Du XJ, et al. I (f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities. Br J Pharmacol. 2004 May;142 (1) :107-12.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched

Alternative Products

CatalogName
T63014-01Ivabradine
RM-I220281-01Ivabradine USP Rc Hydroxy Ivabradine
RM-I220248-01Ivabradine USP Rc Ivabradine Amine
RM-I220246-01Ivabradine USP Rc N-Desmethyl Ivabradine
RM-I220202-01Ivabradine USP Rc Ivabradine Open Ring
OR1039743Ivabradine metabolite N-Demethyl Ivabradine (hydrochloride)
RM-I220205-01Ivabradine Impurity E (8-Demethyl Ivabradine)
TRC-D229135-5MGDehydro Ivabradine
TRC-I477220-25MGIvabradine Dimer
RM-I220200-01Ivabradine Hydrochloride

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