Duloxetine-d7

CAT: 0804-HY-B0161SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0161SSize:1 mg
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Description
Duloxetine-d7 ((S) -Duloxetine-d7) is the deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) [1][2].
CAS Number
[919514-01-5]
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Serotonin Transporter
Type
Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
97.32
Solubility
10 mM in DMSO
Smiles
O([C@@H](CCNC)C1=CC=CS1)C=2C3=C(C(=C(C2[2H])[2H])[2H])C(=C(C(=C3[2H])[2H])[2H])[2H]
Molecular Formula
C18H12D7NOS
Molecular Weight
304.46
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]De Berardis, D., et al., The effect of newer serotonin-noradrenalin antidepressants on cytokine production: a review of the current literature. Int J Immunopathol Pharmacol, 2010. 23 (2) : p. 417-22.|[3]Wang, S.Y., J. Calderon, and G. Kuo Wang, Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology, 2010. 113 (3) : p. 655-65.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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TRC-D721002-1MGDuloxetine-d7
D9825-01Duloxetine-naphthyl-d7
011013Duloxetine-d7 Maleate
MBS6063365-01(S)-Duloxetine-d7 Succinamide
TRC-M303882-5MGN-Methyl Duloxetine-d7
TRC-N424751-10MGN-Nitroso Duloxetine-d7
011017S-Duloxetine-d7 Succinamide
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