Duloxetine-d3 (hydrochloride)

Duloxetine-d3 (hydrochloride)

• CAS Number: 1435727-97-1
• UNSPSC Description: Duloxetine-d3 (hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].
• Target Antigen: Serotonin Transporter
• Type: Isotope-Labeled Compounds
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: [2H]C([2H])([2H])NCC[C@H](OC1=CC=CC2=C1C=CC=C2)C3=CC=CS3.[H]Cl
• Molecular Weight: 336.89
• References & Citations: [1]De Berardis, D., et al., The effect of newer serotonin-noradrenalin antidepressants on cytokine production: a review of the current literature. Int J Immunopathol Pharmacol, 2010. 23(2): p. 417-22.|[2]Wang, S.Y., J. Calderon, and G. Kuo Wang, Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology, 2010. 113(3): p. 655-65.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported